METABOLISM OF PHTHALIDYL THEOPHYLLINE IN RAT LIVER
スポンサーリンク
概要
- 論文の詳細を見る
Phthalidyl theophylline (PH-TH) in rat liver was metabolized by a hydrolase to theophylline (TH) and 2-carboxybenzaldehyde, and the latter was further metabolized to 2-hydroxymethylbenzoic acid by an nicotinamide adenine dinucleotide-dependent reductase. The hydrolase could be strongly inhibited by acetazolamide, therefore, urinary excretion of PH-TH metabolites was significantly retarded when PH-TH and acetazolamide were coadministered to rats. The results from in vivo experiments suggest that PH-TH was efficiently absorbed from the gastrointestines and metabolized extensively by the liver.
- 公益社団法人日本薬学会の論文
著者
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Hirata M
塩野義製薬
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Hirata Masaharu
Shionogi Research Lab. Kanzakigawa Lab.
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Tonda Kanya
Shionogi Research Laboratories Shionogi & Co. Ltd.
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