EFFECT OF β-LACTAM ANTIBIOTICS ON HEPATOCELLULAR GLUTATHIONE LEVELS IN VITRO AND IN VIVO

スポンサーリンク

概要

• 論文の詳細を見る

• Incubation of isolated rat hepatocytes with high concentration of β-lactam antibiotics, cephaloridine (CER), flomoxef (FMOX) or cephamandole (CMD), resulted in significant reduction of cellular glutathione (GSH) levels, though cell viability was not affected during the incubation period. I.v. injection of a large dose, 300 mg/kg, of these β-lactam antibiotics to rats did not affect the hepatic GSH levels. The concentration of β-lactam antibiotics in the body fluid of the rats were found to be much lower than the amounts which causes GSH depletion in vitro.

• 日本トキシコロジー学会の論文
• 1988-02-25

著者

• Hirata M

  Satfty Res. Inst. Chemical Compounds Co. Ltd. Hokkaido Jpn

• Hirata Masaharu

  Shionogi Research Lab. Kanzakigawa Lab.

• HIGAKI Junko

  Shionogi Research Laboratories, Shionogi and Co., Ltd.

• Higaki Junko

  Shionogi Research Laboratories Shionogi And Co. Ltd.

関連論文

• STUDIES ON THE MECHANISM OF HYDRAZINES FORMATION FROM ISONIAZID AND THEIR DISTRIBUTION IN THE MAIN ORGANS
• METABOLISM OF ISONIAZID AND FREE HYDRAZINE FORMATION IN ISOLATED RAT HEPATOCYTES
• PROTECTIVE EFFECT OF PROSTAGLANDIN A_2-TREATMENT ON MENADIONE-MEDIATED CELL INJURY
• PLASMA BIOCHEMISTRY VALUES OF YOUNG BEAGLE DOGS
• B-36 APPLICATION OF THCHNICON THMS H・1 AUTOANALYZER FOR THE TOXICITY STUDY OF EXPERIMENTAL ANIMALS
• METABOLISM OF PHTHALIDYL THEOPHYLLINE IN RAT LIVER
• HETEROGENEITY OF ISOLATED RAT HEPATOCYTES
• METABOLISM AND ANTITUMOR ACTIVITY OF 1-PHTHALIDYL 5-FLUOROURACIL
• Structure-Melanotropic Activity Relationship in Synthetic Polypeptides Related to ACTH
• EFFECT OF β-LACTAM ANTIBIOTICS ON HEPATOCELLULAR GLUTATHIONE LEVELS IN VITRO AND IN VIVO

スポンサーリンク