Failure of Intrahypothalamic Implants of Antiestrogen, MER-25, to Inhibit Androgen-Sterilization in Female Rats
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概要
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Two-day-old female rats were given bilateral implants of small pellets each containing 5μg MER-25 in bone wax in the medial preoptic to ventromedial areas of the hypothalamus. At the same time, the rats received a single subcutaneous injection of 50μg testosterone propionate. Ovaries of the rats were examined by laparotomy for the presence of corpora lutea at 50 days of age. At 100 days, ovaries were removed and studied histologically. Sterilizing action of testosterone propionate was not inhibited by intrahypothalamic implants of MER-25, at least the present experimental conditions.
- 社団法人 日本内分泌学会の論文
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