Intrahypothalamic Implants of Testosterone or Dihydrotestosterone in Neonatal Female Rats with Reference to Induction of Sterility
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概要
- 論文の詳細を見る
Implants of paraffin micropellets containing about 5μg 5α-dihydrotestosterone (DHT) into the hypothalamus of 5-day-old female rats were without effect on the sexual differentiation of the brain. By contrast, approximately the same amount of testosterone propionate (TP) given as subcutaneous or intrahypothalamic micropellets masculinized the female brain. In the light of these results as well as the authors previous findings that an antiestrogen implanted into the hypothalamus of neonatal female rats failed to block masculinization by subcutaneous injection of TP, the possibility cannot be excluded that testosterone is capable of masculinizing the brain of neonatal females without being converted into estrogens.
- 社団法人 日本内分泌学会の論文
著者
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Hayashi Shinji
Endocrinology Lab. Graduate School Of Yokohama City Uiversity
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Hayashi Shinji
Endocrinology Division National Cancer Center Research Institute
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