Sterility and Delayed Vaginal Opening Following Electrolytic Lesions Placed Neonatally in the Medial Preoptic Area in Female Rats

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Electrolytic lesions were placed in the preoptic area or in the middle and posterior hypothalamus of female rats within 48 hrs after birth. Vaginal opening was delayed significantly in rats having the medial preoptic area (mPOA) destructed as compared to sham-operated animals and those given lesions in the other parts of the hypothalamus. Only rats with the mPOA completely destructed developed the anovulatory syndrome. In these animals, unilateral ovariectomy was not followed by enlargement of its fellow. The present results are not in agreement with those of previous workers that electrolytic destructions of the diencephalon induced precocious puberty. The difference may be ascribable to difference in size and locus of lesions.
社団法人日本内分泌学会の論文