Sterilization of Female Rats by Neonatal Placement of Estradiol Micropellets in Anterior Hypothalamus
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概要
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A pair of micropellets of a 1% or 10% estradiol (E<SUB>2</SUB>)-paraffin mixture (containing 0.2 or 2μg E<SUB>2</SUB>, respectively) or paraffin alone were implanted subcutaneously or intracerebrally in 5-day-old female rats. Animals given 10% E<SUB>2</SUB> pellets became sterilized regardless of loci of the pellets. Of those which had received 1% E<SUB>2</SUB> pellets, only animals with micropellets in the anterior hypothalamus became sterilized. It is suggested that neuronal components which are affected irreversibly by neonatal estrogen treatment are localized in the anterior hypothalamus.
- 社団法人 日本内分泌学会の論文
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