Effects of Calcium Ionophore (A-23187) on Glucose Oxidation and Iodide Transport in Dog Thyroid Slices
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概要
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A calcium ionophore (A-23187, 20μg/m<I>l</I>) stimulated<SUP>14</SUP>C-1-glucose oxidation in dog thyroid slices to an extent equivalent to that obtained by the optimal concentration of dibutyryl cyclic AMP (1mM). Furthermore, the ionophore augmented the stimulation by dibutyryl cyclic AMP much more than the simple additive effect. The ionophore also enhanced the effect of TSH, but to a lesser extent.<BR>Under conditions where organic binding was blocked, T/M ratio of radioiodine concentration was lowered in slices by the ionophore; the findings similar to those obtained with TSH and dibutyryl cyclic AMP.<BR>The ionophore exhibited a slightly depressive effect on the basal cyclic AMP level. The elevation by TSH of cyclic AMP levels was also slightly depressed by the ionophore, but statistically insignificant in most cases.<BR>These results indicate that calcium ion may play an important role in the TSH regulation of iodide transport and glucose metabolism in the thyroid, in some cases by augmenting the effects of cyclic AMP.
- 社団法人 日本内分泌学会の論文
著者
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Oka Hiroshi
First Department Of Internal Medicine Tokyo University
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AIYOSHI YUJI
Section of Surgery, Central Hospital of Ibaraki
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YAMASHITA KAMEJIRO
Section of Endocrnology and Metabolism, Department of Medicine, University of Tsukuba, School of Med
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OGATA ETSURO
Section of Endocrinology and Metabolism, Department of Medicine, University of Tsukuba School of Med
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Oka Hiroshi
First Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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AIYOSHI YUJI
Section of Endocrinology and Metabolism, Department of Medicine, University of Tsukuba School of Medicine
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YAMASHITA KAMEJIRO
Section of Endocrinology and Metabolism, Department of Medicine, University of Tsukuba School of Medicine
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OGATA ETSURO
Section of Endocrinology and Metabolism, Department of Medicine, University of Tsukuba School of Medicine
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