Effect of Glucose Adenosine on 3, 5-Monophosphate Levels in Rat Pancreatic Islets
スポンサーリンク
概要
- 論文の詳細を見る
Time course of the changes in insulin release and cyclic AMP levels in isolated rat islets incubated in media containing 5 or 16.7mM of glucose were followed.<BR>The higher glucose concentration caused a slight but significant increase of cyclic AMP levels after 10min incubation, but not 5min incubation, whereas the stimulation of insulin release by 16.7mM of glucose was apparent in both incubation times.<BR>Theophylline increased cyclic AMP levels markedly but did not stimulate insulin release when the glucose concentration was 5mM. A slight augmentation by theophylline of insulin release was observed in the incubation medium containing 16.7mM glucose.<BR>All these findings suggest that the elevation of cyclic AMP in islets may not play a role for the initiation of the insulin release induced by glucose, though it may act to modulate the glucose effect.
- 社団法人 日本内分泌学会の論文
著者
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Yasuda Hiroko
The First Department Of Internal Medicine University Of Tokyo
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Oda Toshitsugu
The First Dept. of Intern. Med. Tokyo Univ. school of Med.
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Suzuki Seiji
First Department Of Internal Medicine Showa University Fujigaoka Hospital
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SUZUKI SEIJI
The First Department of Medicine, Uniuersity of Tokyo, Faculty of Medicine
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OKA HIROSHI
The First Department of Medicine, Uniuersity of Tokyo, Faculty of Medicine
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KANEKO TOSHIO
The First Department of Medicine, Uniuersity of Tokyo, Faculty of Medicine
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YAMASHITA KAMEJIRO
Section of Endocrnology and Metabolism, Department of Medicine, University of Tsukuba, School of Med
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YAMASHITA KAMEJIRO
Section of Endocrinology and Metabolism, Department of Medicine, University of Tsukuba School of Medicine
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YASUDA HIROKO
The First Department of Medicine, University of Tokyo, Faculty of Medicine
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SUZUKI SEIJI
The First Department of Medicine, University of Tokyo, Faculty of Medicine
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ODA TOSHITSUGU
The First Department of Medicine, University of Tokyo, Faculty of Medicine
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