Effect of Sulpiride on Serum Growth Hormone and Prolactin Concentrations Following L-DOPA Administration in Man

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概要

• 論文の詳細を見る

• The effect of chronic administration of sulpiride on serum human growth hormone (hGH), prolactin and thyroid stimulating hormone (TSH) was examined in 6 normal subjects. Sulpiride was given orally at a dose of 300 mg (t. i. d.) for 30 days. Sulpiride raised serum prolactin levels in all subjects examined. In addition, sulpiride suppressed hGH release induced by L-dopa, although the basal hGH level was not changed. Sulpiride treatment appeared to antagonize partially the inhibitory effect of L-dopa on prolactin release. Following thyrotropin-releasing hormone (TRH) injection, the percent increment in prolactin levels from the baseline in sulpiridetreated subjects was less than in controls without sulpiride. In contrast, both the basal and TRH-stimulated TSH levels were not influenced by sulpiride.<BR>These observations suggest that sulpiride suppressses L-dopa-induced hGH release and stimulates prolactin release, presumably by acting against the dopaminergic mechanism, either on the hypothalamus or on the pituitary. The decreased prolactin response to TRH after sulpiride treatment may indicate a diminished reserve capacity in pituitary prolactin release.

• 社団法人 日本内分泌学会の論文

著者

• Kobayashi Isao

  Division of Clinical Endocrinology, Department of Medicine, School of Medicine, Gunma University

• Fukuda Hitoshi

  First Department of Internal Medicine, School of Medicine Gunma University

• MORI MASATOMO

  Division of Endocrinology, Department of Medicine, Gunma University Hospital

• SHIMOYAMA SADAO

  First Department of Internal Medicine, School of Medicine, Gunma University

• UEHARA TERUO

  First Department of Internal Medicine, School of Medicine, Gunma University

• NEMOTO TOSHIKAZU

  First Department of Internal Medicine, School of Medicine, Gunma University

• KAMIOI NOBUYUKI

  Division of Endocrinology, Department of Medicine, Gunma University

• Fukuda Hitoshi

  First Department Of Internal Medicine School Of Medicine Gunma University

• Mori M

  Gunma Univ.

• Kobayashi Isao

  Division Of Clinical Endocrinology Department Of Medicine School Of Medicine Gunma University

• KOBAYASHI ISAO

  Division of Endocrinology, Department of Medicine, Gunma University

• FUKUDA HITOSHI

  First Department of Internal Medicine, School of Medicine, Gunma University

• MORI MASATOMO

  Division of Endocrinology, Department of Medicine, Gunma University

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