Effect of Active and Passive Immunization with TRH on Plasma TSH Response to Propyithiouracil
スポンサーリンク
概要
- 論文の詳細を見る
The role of thyrotropin-releasing hormone (TRH) in the secretion of TSH from the anterior pituitary was investigated in rats by active and passive immunization with TRH.<BR>The plasma TSH response to propylthiouracil (PTU) in TRH-bovine serum albumin (BSA)-immunized rats was significantly lower than that of BSA-immunized or non-immunized rats. Similarly, the increased plasma TSH level following PTU treatment was significantly suppressed after iv injection of antiserum to TRH. However, the decline in plasma TSH levels was not complete.<BR>The results of the present study indicate, at least in part, the physiological significance of endogenous TRH in the regulation of pituitary TSH secretion.
- 社団法人 日本内分泌学会の論文
著者
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Fukuda Hitoshi
Division of Clinical Endocrinology, Department of Medicine, School of Medicine, Gunma University
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Kobayashi Isao
Division of Clinical Endocrinology, Department of Medicine, School of Medicine, Gunma University
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WAKABAYASHI KATSUMI
Division of Pharmaceutical Sciences, National Institute of Radiological Sciences
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MORI MASATOMO
Division of Endocrinology, Department of Medicine, Gunma University Hospital
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OHSHIMA KIHACHI
Division of Endocrinology, Department of Medicine, Gunma University Hospital
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SHIMOMURA YOHNOSUKE
Division of Endocrinology, Department of Medicine, Gunma University Hospital
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Fukuda Hitoshi
Division Of Clinical Endocrinology Department Of Medicine School Of Medicine Gunma University
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Mori M
Gunma Univ.
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Kobayashi Isao
Division Of Clinical Endocrinology Department Of Medicine School Of Medicine Gunma University
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KOBAYASHI ISAO
Division of Endocrinology, Department of Medicine, Gunma University Hospital
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WAKABAYASHI KATSUMI
Division of Pharmaceutical Sciences National Institute of Radiological Sciences
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FUKUDA HITOSHI
Division of Endocrinology, Department of Medicine, Gunma University Hospital
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WAKABAYASHI KATSUMI
Division of Endocrinology, Department of Medicine, Gunma University Hospital
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MORI MASATOMO
Division of Endocrinology, Department of Medicine, Gunma University
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