Effect of .GAMMA.-oryzanol on serum TSH concentrations in primary hypothyroidism.

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概要

• 論文の詳細を見る

• A single oral dose (300mg) of γ-oryzanol extracted from rice-bran oil produced a significant reduction on the elevated serum TSH levels in hypothyroid patients. Similarly, chronic treatment with γ-oryzanol resulted in decreased serum TSH levels in 6 of 8 patients. There was no change in the serum levels of thyroxine-iodine and triiodothyronine during the study. In addition, there was no difference in the serum TSH response to TRH in hypothyroid patients and normal subjects.<BR>These observations suggest that γ-oryzanol inhibits serum TSH levels in patients with primary hypothyroidism, possibly by a direct action at the hypothalamus rather than the pituitary.

• 社団法人 日本内分泌学会の論文

著者

• MORI MASATOMO

  Division of Endocrinology, Department of Medicine, Gunma University Hospital

• OHSHIMA KIHACHI

  Division of Endocrinology, Department of Medicine, Gunma University Hospital

• SHIMOMURA YOHNOSUKE

  Division of Endocrinology, Department of Medicine, Gunma University Hospital

• Fukuda Hitoshi

  Division Of Clinical Endocrinology Department Of Medicine School Of Medicine Gunma University

• MARUTA SAKAE

  Division of Endocrinology, Department of Medicine, Gunma University School of Medicine

• Kobayashi Isao

  Division Of Clinical Endocrinology Department Of Medicine School Of Medicine Gunma University

• KAMIO NOBUYUKI

  Division of Endocrinology, Department of Medicine, Gunma University Hospital

• MARUTA SAKAE

  Division of Endocrinology, Department of Medicine, Gunma University Hospital

• MORI MASATOMO

  Division of Endocrinology, Department of Medicine, Gunma University

関連論文

• Nyctohemeral Rhythm of Plasma Thyrotropin and its Regulation by Central Nervous System
• Effect of Active and Passive Immunization with TRH on Plasma TSH Response to Propyithiouracil
• Effect of Sulpiride on Serum Growth Hormone and Prolactin Concentrations Following L-DOPA Administration in Man
• Studies on the T3 Suppression Test by the 24-Hour Thyroidal 131I Uptake in Patients with Graves Disease: Comparison of the Effects of Propylthiouracil and Methylmercaptoimidazole
• Effect of .GAMMA.-oryzanol on serum TSH concentrations in primary hypothyroidism.
• Tsh and prolactin secretions in hashimoto's thyroiditis following withdrawal of thyroid hormone therapy.
• Potentiation by indomethacin of TRH-induced TSH secretion in the rat.

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