Potentiation by indomethacin of TRH-induced TSH secretion in the rat.

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概要

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• We have studied the effect of two inhibitors of prostaglandin synthesis on the basal and TRH-stimulated plasma TSH levels in the rat. Animals were injected sc daily with indomethacin (3mg/0.5m<I>l</I>) or aspirin (16-30mg/0.5m<I>l</I>) for3days. The plasma T<SUB>4</SUB> and T<SUB>3</SUB> were consistently lower in the indomethacin or aspirin groups than in the controls, while the basal TSH levels did not change. Indomethacin treatment significantly potentiated the TSH response to synthetic TRH (200ng, iv) in intact and thyroidectomized rats. The pituitary TSH content was markedly increased by indomethacin, while hypothalamic TRH content did not change. In contrast, aspirin inhibited the TSH response to TRH in intact rats, when pituitary TSH content decreased significantly. No potentiation by aspirin of TRH-stimulated TSH response in thyroidectomized rats was observed.<BR>The increased sensitivity of plasma TSH response to exogenous TRH in the indomethacin group is presumably due to higher pituitary TSH content than in the controls. The action of indomethacin appears to be mediated, at least in part, at the pituitary level. In addition, there is a dissociation between the action of indomethacin and the action of aspirin in the TSH response to TRH.

• 社団法人 日本内分泌学会の論文

著者

• Kobayashi Isao

  First Department Of Internal Medicine Gunma University

• MORI MASATOMO

  Division of Endocrinology, Department of Medicine, Gunma University

• Tsuyusaki Kazutoshi

  Division of Endocrinology, Department of Medicine, Gunma University Hospital

• TONOOKA NOBUHIKO

  First Department of Internal Medicine, School of Medicine, Gunma University

• TONOOKA NOBUHIKO

  First Department of Internal Medicine, School of Medicine Gunma University

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• Potentiation by indomethacin of TRH-induced TSH secretion in the rat.

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