Further Analysis of the Positive Feedback Effects of Estrogen on the Release of Gonadotropin in Women
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概要
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The present experiments were designed to clarify the mechahism of the positive feedback action of estrogen on gonadotropin release. Since a precise hormonal sequence of estrogen and gonadotropin during the induction of gonadotropin surge had been revealed in our previous study (Araki <I>et al</I>., 1978), the same experimental model was used with an additional stimulus of Gn-RH.<BR>The pituitary responsiveness to exogenous Gn-RH during the constant infusion of estradiol-17β was studied in 8 women. The infusion was initiated on various days of the follicular phase and maintained for 66 hr at a constant rate of 500 μg/24 hr which effected final increments of approximately 200-400 pg/ml in circulatory estradiol. Ten or one hundred μg of Gn-RH dissolved in saline was administered i.v. at 3 different times; before estradiol treatment, and 24 hr and 60-64 hr after the onset of the infusion.<BR>In the early f ollicular phase, a markedly decreased responsiveness of the pituitary was observed after the second stimulation of Gn-RH. The suppressive effect of estrogen was not observed in subjects in the mid-follicular phase. The maximal LH response to Gn-RH was seen near or in coincidence with LH surge induced by the stimulus of estradiol.<BR>A prolonged time course during the stimulation of estrogen was divided into 3 different phases: the negative feedback, transition and positive feedback. It is suggested that prolonged exposure to preovulatory levels of estrogen leads to a marked increase in pituitary responsiveness which may elicite LH surge in the absence of a greatly increased release of Gn-RH.
- 社団法人 日本内分泌学会の論文
著者
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Tamada Taro
Department Of Community And Family Medicine Jichi Medical School
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Minakami Hisanori
Department Of Gynecology Hokkaido University
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Araki Shigeo
Department Of Neurology Kawasaki Cooperation Hospital
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Araki Shigeo
Department Of Obstetrics And Gynecology Jichi Medical School
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AKABORI AKIO
Department of Obstetrics and Gynecology Jichi Medical School
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CHIKAZAWA KOHSHIRO
Department of Obstetrics and Gynecology, Jichi Medical School
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AKABORI AKIO
Department of Obstetrics and Gynecology, Jichi Medical School
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