Plasma Active and Inactive Renin in Patients with Diabetes Mellitus
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概要
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Plasma active and acid activated inactive renin was measured in healthy subjects and in patients with diabetes mellitus. The angiotensin I generated from the incubation of non-acidified plasma with pig renin substrate was expressed as plasma renin concentration (<B>PRC</B>) and that from acidified plasma was expressed as total renin concentration (<B>TRC</B>). The inactive renin concentration (<B>IRC</B>) was calculated as <B>TRC</B> minus <B>PRC</B>. With regard to plasma renin activity (<B>PRA</B>) and <B>PRC</B>, no significant difference was found between normal and diabetic groups. <B>TRC</B> and <B>IRC</B> in diabetics with no clinical sign of microangiopathy were22.8±1.7and15.2±1.3 ng/m<I>l</I>/h (mean±SE), and these values were not significantly different from those in the healthy subjects (20.5±1.5and13.2±1.5ng/m<I>l</I>/h). However, <B>TRC</B> and <B>IRC</B> in diabetics with retinopathy and clinical nephropathy was38.8±3.4and30.7±3.2ng/m<I>l</I>/h, and these values were significantly higher than those in the above two groups, respectively. Moreover <B>TRC</B> and <B>IRC</B> in diabetics with retinopathy and no clinical nephropathy was33.8±5.7and24.9±5.5ng/m<I>l</I>/h, and these values were significantly higher than those in the control group. <B>IRC</B> was not significantly correlated with fasting blood sugar and mean blood pressure levels, however a significant correlation was found between <B>IRC</B> and <B>BUN</B>, and <B>IRC</B> and P. S. P. excretion in 15 minutes.<BR>These findings suggest that increased inactive renin in diabetes mellitus may be related to the progression of the renal lesions associated with diabetic microangiopathy.
- 社団法人 日本内分泌学会の論文
著者
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Wada Masahisa
Second Dept. Of Intern. Med. Osaka City Univ. School Of Med.
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Funae Yoshihiko
Laboratory Of Chemistry Osaka City University
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FUJII SATORU
Second Department of Internal Medicine Osaka City University Meaical School
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SHIMOJO NOBUO
Second Department of Internal Medicine Osaka City University Meaical School
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FUNAE YOSHIHIKO
Laboratory of Chemistry Osaka City University Meaical School
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WADA MASAHISA
Second Department of Internal Medicine Osaka City University Meaical School
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