Plasma Inactive Renin in Patients with Diabetes Mellitus: Effects of Standing and the Relation to Serum Protease Inhibitor

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In order to investigate the mechanisms of increased plasma inactive renin in diabetics with diabetic microvascular complications, changes in active and inactive renin with the progress of diabetes mellitus were studied, and effects of standing on inactive renin release and the relationship between plasma inactive renin and serum trypsin or protease inhibitors were also studied. Inactive renin increased with the aggravation of diabetes mellitus, but active renin didnt show significant changes with the aggravation of diabetes mellitus. Active renin was significantly increased both in the healthy subjects and in the diabetic patients when they were in an upright position, but no significant change was observed in inactive renin. Serum trypsin in diabetics with retinopathy and nephropathy was lower than that in those with no clinical sign of microangiopathy, but the correlation between plasma inactive renin and serum trypsin was not significant. There was a significant correlation between plasma inactive renin and serum α2-globulin (r=0.52, p<0.01). Although plasma inactive renin was not significantly correlated with serum α1-antitrypsin, there was a significant correlationbetween plasma inactive renin and serum α2-macroglobulin (r=0.61, p<0.01).<BR>These results show that the increased levels of plasma inactive renin observed with the development of diabetic microangiopathy are probably related to the altered plasma protein metabolism observed in patients with diabetes mellitus. However, it is not clear whether this altered protein metabolism is related to the conversion from inactive to active renin.
社団法人日本内分泌学会の論文

Plasma Inactive Renin in Patients with Diabetes Mellitus: Effects of Standing and the Relation to Serum Protease Inhibitor

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