The Effects of Dopamine on Renal Excretion of Sodium, Phosphate and Cyclic AMP in Thyroparathyroidectomized Dogs
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概要
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With dopamine (0.5μg/kg/min) infusion into the renal artery of thyroparathyroidectomized dogs, urine output and inorganic phosphate excretion increased significantly (p<0.05), but the increase in sodium excretion was low and not statistically significant. However, natriuresis and phosphaturia due to the infusion of dopamine were accelerated more markedly by the pretreatment with phenoxybenzamine. Dopamine was infused into the renal artery in doses too small to affect renal hemodynamics (0.02-0.05μg/kg/min) after the treatment with phenoxybenzamine and alprenolol with the result that phosphate and sodium excretion increased significantly (p<0.05). The excretion rate of cAMP did not change. This suggests that the effect of dopamine on sodium and phosphate excretion is directly influenced by alpha adrenergic activity in the kidney. The mechanism of natriuresis and phosphaturia by dopamine is, however, independent of changes in parathyroid hormone and the adenyl cyclase-cAMP system.
- 社団法人 日本内分泌学会の論文
著者
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Goto Fumio
Department Of Anesthesilogy Kitasato University School Of Medicine
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GOTO FUMIO
Department of Anesthesiology, Gunma University Hospital
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