Aquaporin-4 is absent at the sarcolemma and at perivascular astrocyte endfeet in α1-syntrophin knockout mice
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概要
- 論文の詳細を見る
α1-Syntrophin, a member of dystrophin-associated proteins, is expressed at the sarcolemma and at perivascular astrocytes, and participates in protein-protein interactions through its PDZ domain. Aquaporin-4 (AQP4) is the predominant water channel protein in the brain, and also expressed at the sarcolemma of fast-twitch muscle fibers. AQP4 is concentrated in orthogonal array particles (OAPs), and its expression has been reported to be decreased at the sarcolemma of dystrophin-deficient mdx mice. We examined whether α1-syntrophin targets AQP4 at the sarcolemma. Immunohistochemistry showed that AQP4 is absent at the sarcolemma in α1-syntrophin knockout mice and that its expression is also lost from the perivascular astrocyte endfeet. On the other hand, expression of AQP4 is not decreased at the sarcolemma of the knockout mice in the neonatal stage. Moreover, AQP4 is expressed in lung, stomach, and kidney of wild-type and α1-syntrophin null mice. Our results show that α1-syntrophin is a key molecule to localize AQP4 to the sarcolemma of mature fast myofibers and astrocyte endfeet, but AQP4 is targeted to the plasma membrane by different molecules in lung, stomach, and kidney.
- 日本学士院の論文
著者
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Hosaka Yukio
Department Of Cardiology Niigata City General Hospital
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SHIBUYA Seiji
Division of Neurology, Department of Medicine, Showa University, Fujigaoka Hospital
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WAKAYAMA Yoshihiro
Division of Neurology, Department of Medicine, Showa University, Fujigaoka Hospital
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Matsuda Ryoichi
Department Of Biological Sciences Graduate School Science The University Of Tokyo Meguro-ku:departme
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Takeda Shinichi
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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YOKOTA Toshifumi
Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology a
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MIYAGOE Yuko
Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology a
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TSUKITA Kayoko
Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology a
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KAMEYA Shuhei
Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology a
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WAKAYAMA Yoshihiro
Division of Neurology, Department of Medicine, Showa University Fujigaoka Hospital
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MIYAGOE Yuko
Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry
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SHIBUYA Seiji
Division of Neurology, Department of Medicine, Showa University Fujigaoka Hospital
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HOSAKA Yukio
Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry
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KAMEYA Shuhei
Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry
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Matsuda Ryoichi
Department of Applied Chemistry Faculty of Engineering Tokushima University
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TSUKITA Kayoko
Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry
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