Inhibitory Effects of Caffeine on Contraction of Depolarized Smooth Muscle.
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概要
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By measuring the isometric tension produced by thin strips of taenia coli smooth muscle, inhibitory effects of caffeine on the acetylcholine (ACh)-induced phasic contraction were examined under the high-K depolarized state. Caffeine (2mM) inhibited ACh-contraction by three different mechanisms: 1) by decreasing the efficiency of Ca-release from Ca-store, 2) by inhibiting the loading of Ca-store with Ca2+ and 3) by accelerating the depletion of Ca-store. In the presence of physiological concentration of Ca2+ the first mechanism was found to be dominant with a slight contribution of the second. Under the nominally Ca-free conditions the contribution of the third was also important.
- 日本学士院の論文
著者
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Yamashita Shigeru
Department Of Biochemistry Toho University School Of Medicine
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YAMASHITA Shigeru
Department of Pharmacology, Faculty of Medicine, University of Tokyo
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- Inhibitory Effects of Caffeine on Contraction of Depolarized Smooth Muscle.