Asymmetric Total Synthesis of Taxol®

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概要

• 論文の詳細を見る

• Asymmetric total syntheses of Taxol and of 8-demethyltaxoids 24-27 from the 8-membered ring compounds 29 and 12 respectively were completed via successive formation of the BC ring system by intramolecular aldol reaction, then the ABC ring system utilizing an intramolecular pinacol cyclization. The conversion of the tricyclic compound 43 to 7-TES baccatin III (49) was carried out by way of a newly devised method of constructing the oxetane ring. The dehydration condensation between a derivative of N- benzoylphenylisoserine and 49, followed by deprotection afforded the antitumor agent Taxol.

• 日本学士院の論文

著者

• Hasegawa Masatoshi

  Department Of Drug Metabolism Research Center Taisho Pharmacetutical Co. Ltd.

• Mukaiyama Teruaki

  Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo

• 椎名 勇

  Department Of Applied Chemistry Faculty Of Science Tokyo University Of Science

• SAKOH Hiroki

  Department of Applied Chemistry, Faculty of Science, Science University of Tokyo

• Iwadare Hayato

  Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo

• TANI Yu-ichirou

  Department of Applied Chemistry, Faculty of Science, Science University of Tokyo

• Shiina Isamu

  Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo

• Saitoh Katsuyuki

  Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo

• Tani Yu-ichirou

  Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo

• Hasegawa Masatoshi

  Department Of Chemistry Faculty Of Science Toho University

• MUKAIYAMA Teruaki

  Department of Applied Chemistry, Faculty of Science, University of Tokyo

• HASEGAWA Masatoshi

  Department of Applied Chemistry, Faculty of Science, University of Tokyo

• IWADARE Hayato

  Department of Applied Chemistry, Faculty of Science, University of Tokyo

• TANI Yu-ichirou

  Department of Applied Chemistry, Faculty of Science, University of Tokyo

• SHIINA Isamu

  Department of Applied Chemistry, Faculty of Science, University of Tokyo

• SAKOH Hiroki

  Department of Applied Chemistry, Faculty of Science, University of Tokyo

• SAITOH Katsuyuki

  Department of Applied Chemistry, Faculty of Science, University of Tokyo

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