DIAGNOSIS OF REYE SYNDROME

概要

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Three patients with acute encephalopathy and evidences of liver damage are presented. One of them was diagnosed as having Reye syndrome on the basis of light microscopic and electron microscopic observations on liver histology as well as clinical and laboratory evidences. Other 2 patients had liver histology different from that seen in Reye syndrome, despite they had clinical features and laboratory findings which were very similar to those of Reye syndrome. We propose from these experiences that diagnosis of Reye syndrome can only be made with histological evidence. Studies on the pathophysiology of other 2 patients who showed very similar metabolic alterations may given an alternative way to reach the essential pathogenesis of Reye syndrome, which may provide us with the possibility of nonhistologic diagnosis of Reye syndrome.
久留米大学医学部 The Kurume Medical Journal 編集部の論文