Morphological study between vascular endotheliums and platelets.

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The endotheliums proliferated most remarkably with platelet concentrated plasma (PCP) reinjected in the blind tubes of rabbits' arteries and completely covered just around the surface of the platelet fibrin mass. But they did'nt react so remarkably with fibrin or red blood cells as PCP and in some cases of the latters the reactive proliferation of endotheliums remained to be the minimum or even could be hardly found.The cultured endotheliums also grew and rose up to wrap the small fragments of platelet fibrin from a layer of the cultured endothelial sheet on the bottom. Their nucli were large and hyperchromatic and it looked like tufting or budding architecture seen in an intravascular papillary endothelial hyperplasia. These findings show that rapid proliferation and covering of endothelium around the platelet fibrin flagments is important as well as infiltrative proliferation of the smooth muscle cells from a inner layer of media in intimal thickening.