Prenatal hydrocortisone administration and lymphocyte response in the neonatal rabbits.
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概要
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The influence of hydrocortisone to lymphocyte response against PHA stimulation was studied in neonatal rabbits. Prenatally, six pregnant rabbits were given hydrocortisone and seven control pregnant rabbits were given physiological saline at the 28th, 29th and 30th day of gestation. After delivery, lymphocytes of the neonates were tested within 48 hours.<BR>The stimulation index after the lymphocytes were cultered with PHA of 1 : 100 was 11. 15 ± 2. 14 in saline-treated control, versus 2.43 ± 1.0 in the steroid-treated group (p<0.005). Similar difference in S. I. was also found with PHA 1 : 1000, 9.56 ± 2.84 in saline versus 1. 54 ± 0. 13 in the steroid group (p<0.02).<BR>Postnatally, neonates were divided into two groups, one was given hydrocortisone, the other saline on the 1st, 2nd and 3rd day of age. The neonates were sacrificed at 72-120 hours of age and the blood collected for lymphocyte studies.<BR>The stimulation index in the treatment neonates with PHA was significantly depressed in the steroid-treated group when the results were compared with the control group. Steroid when administered prenatally or postnatally, suppresses lymphocyte function in the neonatal rabbits.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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YOKOYAMA M.
Department of Anstomy, Shimane Medical University Department of Molecular Life Science II, School of
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GUPTA MADAN
Departments of Pediatrics and Pathology, University of Illinois College of Medicine Chicago
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VIDYASAGAR DHARMATURI
Departments of Pediatrics and Pathology, University of Illinois College of Medicine Chicago
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ZARIFF MEHRUNNISSA
Departments of Pediatrics and Pathology, University of Illinois College of Medicine Chicago
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