Experimental studies on the relationship between bile acid and bilirubin excretion in the rat after relief of biliary obstruction.

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To study the effects of bile acid on bile secretion in the rats with relieved biliary obstruction, Wistar rats were prepared by ligation of the common bile duct for 1 to 2 weeks and relieving the obstruction 48 hours prior to the study. Bile flow, bilirubin excretion rate, and HCO-3 output were observed during either sodium taurocholate or sodium dehydrocholate infusion. The results were as follows: a) Bile salt-induced choleretic effect was significantly augmented in the jaundiced rats as compared with controls. b) Sodium taurocholate infusion caused a marked increase in bilirubin excretion, whereas a very small increase caused sodium dehydrocholate. c) While bile salts infusion caused a marked decrease in biliary concentration of bicarbonate, it substantially caused a significant increase in bicarbonate output. In conclusion, effective reduction of jaundice after biliary decompression might be achieved by supplemental administration of micelle-forming bile acid provided that hepatic clearance of bile acid remains intact.