Localization of Cu, Zn-Superoxide dismutase (SOD) in the liver tissue of patients with liver diseases by immunoperoxidase technique; light and electron microscopic studies.:Light and electron microscopic studies

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The localization of Cu, Zn-SOD in the liver tissue was studied by using an immunoperoxidase technique. Cu, Zn-SOD was localized in the nucleus and cytoplasm of hepatocytes by light microscope. The intensity of distribution of Cu, Zn-SOD stain was marked in such liver cells as those close to fibrosis, or either those with fatty degeneration or with ballooning degeneration. So Cu, Zn-SOD was speculated to be produced against the toxic effect of superoxide radical causing ischemia or degeneration.<BR>By immunoelectron microscope, Cu, Zn-SOD was observed at endoplasmic reticulum, perinuclear space, cytoplasmic vesicles and Golgi apparatus in the hepatocytes. Moreover, Cu, Zn-SOD was also seen around fat depositted area within hepatocytes, while in liver cirrhosis Cu, Zn-SOD was also on cell membrane. Thus, our immunoelectron microscopic study might suggest that Cu, Zn-SOD was producted and secreted in the hepatocytes representing cytoprotective mechanism.
社団法人日本肝臓学会の論文