Effect of Xiao-Chai-Hu-tang on paraquat-induced liver injury.

概要

論文の詳細を見る
By means of liver slice culture, the suppressive effect of Xiao-Chai-Hu-Tang on hepatic injury due to paraquat (PQ2+, 1, 1'-dimethyl-4-4'-bipyridinium ion, methyl viologen) was examined in terms of released GOT, LPO in liver slices and histologic features of he liver. Then, the effects of Xiao-Chai-Hu-Tang on hepatic microsomal lipid peroxidation mediated by PQ2+ were studied. The results were as follows. 1) Upon liver slice culture, Xiao-Chai-Hu-Tang showed dose-dependent suppression of PQ2+-induced hepatic injury. Although Xiao-Chai-Hu-Tang suppressed hepatic injury regardless of whether it was added to the medium before (Prior administration group), at the same time as (Administration together with PQ2+ group) or after (Subsequent administration group) the addition of PQ2+, the suppression was most marked in the case of prior administration, followed by administration together with PQ2+. 2) Xiao-Chai-Hu-Tang suppressed hepatic microsomal lipid peroxidation mediated by PQ2+, liver microsomes and the NADPH generating system. Among galenicals constituting Xiao-Chai-Hu-Tang, Scutellariae Radix, Glycyrrhizae Radix and Bupleuri Radix were found to suppress hepatic microsomal lipid peroxidation. These results suggest that Xiao-Chai-Hu-Tang suppresses active oxygen-induced hepatic injury.
社団法人日本肝臓学会の論文