The difference of infection pattern of Duck hepatitis B virus with special relationship to the ontogeny of immune response in ducklings.

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概要

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• To investigate the relationship between the host immune state and the difference of infection pattern of Duck hepatitis B virus (DHBV), each 5 ducklings of 1, 7, 14 and 42 day old were immunized with Brucella abortsu and Rabbit erythrocyte and the titer of antibody against these immunogens was measured by microtitration assay weekly after the immunization.<BR>Inoculation of DHBV on 1 day, 7 day and on above 14 day posthatch resulted in persistent, transient and non-infection respectively. Significant difference was seen in immune response at the first week after immunization between ducklings immunized on 1 day old and those on above 7 days old. Peak titer of antibodies were not significantly different among these ducklings.<BR>Investigation of immune response in ducklings treated with immuno-regulatory drugs showed no significant difference both in ducks treated with OK-432 and steroid. Treatment with cyclophosphamide decrease the immune response and the poor immune response was well associated with the elongation of viremia.<BR>Therefore, difference of the infection pattern of DHBV appeared to be closely associated with the immune state of duckling.

• 社団法人 日本肝臓学会の論文

著者

• 日高 光宣

  島根医科大学内科学講座第2

• 日高 光宣

  島根医科大学第2内科

関連論文

• アヒルB型肝炎ウイルスの感染様式に及ぼすステロイド剤の影響
• ヘパドナウイルスの感染様式に及ぼす参三七と猪苓多糖の影響 : アヒルB型肝炎ウイルスを用いた検討
• アヒルB型肝炎ウイルスの免疫組織学的研究 : フ化当日及びフ化7日目ウイルス接種アヒルにおける肝内DHBVの広がりと壊死,炎症性細胞の進展の関連
• The effects of steroid hormone and cyclophosphamide on elongation of viremia of duck hepatitis B virus.
• The difference of infection pattern of Duck hepatitis B virus with special relationship to the ontogeny of immune response in ducklings.

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