Effect of dibutyryl cyclic AMP and glucagon on liver adenine nucleotide metablism in rats with acute hepatic failure.

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Effect of dibutyryl cyclic AMP (DBcAMP) and glucagon on liver adenine nucleotide metabolism in hepatitis induced by D-galactosamine (GalN) was investigated. In normal rats, after the administration of two stimulators, hepatic ATP level decreased slightly and transiently, with concomitant increased in ADP and AMP. It was posturated that both stimulators enhanced ATP-utilizing metabolic processes such as gluconeogenesis.<BR>Reduction of all adenine nucleotides level occurs in liver tissue severly damaged by GalN; this reflects the marked loss of viable hepatocytes. However, the level of all adenine nucleotides was restored by DBcAMP and glucagon administration in GalN treated rats. Different metabolic response was recognized between DBcAMP and glucagon. DBcAMP brought about higher level of hepatic ATP than glucagon in GalN treated rats.<BR>Thease findings suggested that DBcAMP was more effective than glucagon especially on liver energy metabolism in GalN treated rats.
社団法人日本肝臓学会の論文