Hepatitis B Virus DNA Integration in Hepatocellular Carcinomas and Their Adjacent Non-neoplastic Liver Tissues
スポンサーリンク
概要
- 論文の詳細を見る
Hepatitis B virus (HBV) DNA integration was studied in 24 hepatocellular carcinoma (HCC) tissues obtained at operations or autopsies. In 11 cases whose sera were positive for hepatitis B virus surface antigen (HBsAg), HBV DNA integration was demonstrated by Southern blot analysis. Only one of 6 cases whose sera were positive for hepatitis B surface antibody (HBsAb) but negative for HBsAg revealed the integration and the other 5 cases revealed no HBV DNA integration. HBV DNA amplification was noted in 4 of these 6 cases in which HBV DNA integration was found when compared with the adjacent liver tissues. The integration pattern of HBV DNA was different in one case between primary HCC tissue and a metastasized lymph node. It is suggested that HBV DNA amplification is not directly related to the development of HCC and that there are polyclonal tumor cells which have different patterns of virus genome integrations.
著者
-
斎藤 英胤
Department of Internal Medicine, School of Medicine, Keio University
-
土屋 雅春
Department of Internal Medicine, School of Medicine, Keio University
-
渡辺 哲
Department Of Public Health School Of Medicine Tokai University
-
岩渕 直人
Department of Internal Medicine, School of Medicine, Keio University
-
Ding Jing-juan
Department of Internal Medicine, School of Medicine, Keio University
-
森實 敏夫
Department of Internal Medicine, School of Medicine, Keio University
-
加川 建弘
Department of Internal Medicine, School of Medicine, Keio University
-
松本 信吾
Department of Internal Medicine, School of Medicine, Keio University
-
熊谷 直樹
Department of Internal Medicine, School of Medicine, Keio University
-
土木 寛二
Department of Internal Medicine, Kitasato Institute Hospital
-
熊谷 直樹
Department of Internal Medicine, Kitasato Institute Hospital, Keio University
-
森實 敏夫
Department of Internal Medicine, Kanagawa Dental College, Keio University
-
土屋 雅春
Department of Internal Medicine, Kitasato Institute Hospital
-
渡辺 哲
Department of Internal Medicine, Tokyo Metropolitan Ohtsuka Hospital
関連論文
- Disappearance of Serum Hepatitis C Virus RNA within Two Days after One Dose Interferon Administration is Predictive for Response to High-dose Interferon-α2b Treatment for Chronic Hepatitis C
- Enhancing Effect of the Liver Extract and Flavin Adenin Dinucleotide Mixture on Anti-viral Efficacy of Interferon in Patients with Chronic Hepatitis C
- Keio Multicenter Trial in High-dose Interferon-α2b Treatment for Chronic Hepatitis C
- Results of the Multicenter Natural Interferon-α Treatment for Chronic Hepatitis C : Correlation between Total Dose, Administration Periods and Efficacy of Therapy
- Expression of Hepatitis B Surface Antigen in Chang Cells Transfected with Hepatitis B Virus DNA
- Hepatitis B Virus DNA Integration in Hepatocellular Carcinomas and Their Adjacent Non-neoplastic Liver Tissues
- Revaluation of Endoscopic Laser Therapy for Treatment of Early Cancer in the Stomach
- Thymectomy in Human Renal Transplantation.
- Quantitative Analysis of Mesenteric Microcirculatory Disturbances Induced by Autonomic Nervous Irritation.
- Gastric Mucosal Injury: Microcirculation and Helicobacter Pylori.
- Thymic abnormalities and autoimmune diseases.
- Proto-oncogene Expression in Three Human Hepatoma Cell Lines, HCC-M, HCC-T and PLC/PRF/5.
- Recent Advances in the Study of Hepatocellular Carcinoma.