Quantitative Analysis of Mesenteric Microcirculatory Disturbances Induced by Autonomic Nervous Irritation.
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概要
- 論文の詳細を見る
In this study, we have demonstrated that repeated electrical stimuli to the artery of the mesenteric pedicle can produce mesenteric microcirculatory disturbance by autonomic nervous irritation in rats. The parameters to demonstrate microcirculatory damage were observed and quantitatively analyzed using the intravital microscopy after electrical stimulation for 40 minutes. The blood flow of arterioles and venules in the mesentery showed ischemia-reperfusion pattern during the repeated electrical stimulations. The diameter of arterioles did not show significant change, while RBC velocity of arterioles was significantly decreased at 30 min after the irritation. The RBC velocity in venules was decreased from the early period to about 20%. But this values were not significantly dropped during the later observation period, suggesting the formation of short circuit flow by passing the collapsed capillary beds. The number of rolling WBC in the venules was notably increased at the time immediately after irritation, and thereafter the number of rolling WBC number was rather reduced. The number of sticking WBC in venules was time-dependently increased and reached its maximum at 30 min. When permeability of venular wall was determined by the injection of pontamine sky blue, significant increase in permeability was already shown immediately after irritation, suggesting that the integrity of microvascular wall was disturbed in this early period. The permeated area expanded thereafter in parallel with the increase in sticking WBC number. From these observations, it is suggested that endothelial cell damage and following leukocyte-endothelium interaction induced by autonomic nerve irritation appear to be an important factor in microcirculatory disturbances.
- The Keio Journal of Medicineの論文
著者
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土屋 雅春
Department of Internal Medicine, School of Medicine, Keio University
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末松 誠
Department of Internal Medicine, School of Medicine, Keio University
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鈴木 秀和
Department of Internal Medicine, School of Medicine, Keio University
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劉 育英
Department of Internal Medicine, School of Medicine, Keio University
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三浦 総一郎
Department of Internal Medicine, School of Medicine, Keio University
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黒瀬 巌
Department of Internal Medicine, School of Medicine, Keio University
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福村 大
Department of Internal Medicine, School of Medicine, Keio University
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鈴木 雅之
Department of Internal Medicine, School of Medicine, Keio University
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土屋 雅春
Department of Internal Medicine, Kitasato Institute Hospital
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