Expression of Two Novel Cytochrome P450 3A131 and 3A132 in Liver and Small Intestine of Domestic Cats
スポンサーリンク
概要
- 論文の詳細を見る
Cytochrome P450 3A (CYP3A) is the major subfamily of CYP, one of the most important metabolizing enzymes for drugs in humans and other mammals. We found two novel CYP3A genes, CYP3A131 and CYP3A132 in domestic cats (Felis catus). Both feline CYP3A proteins consist of 504 deduced amino acids and show high identity with canine CYP3A homologues and those of some artiodactyls. CYP3A131 transcripts were expressed predominantly in liver and small intestine, and to a negligible extent in other tissues, including brain, heart, kidney and lung. CYP3A132 expression was only detected in liver with much lesser amount. These results suggest the possible major role of CYP3A131 in xenobiotic metabolism including first-pass effects in domestic cats.
著者
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KOMATSU Tetsuya
School of Veterinary Medicine, Rakuno Gakuen University
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HONDA Kouichi
School of Veterinary Medicine, Rakuno Gakuen University
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KUBOTA Akira
School of Veterinary Medicine, Rakuno Gakuen University
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KITAZAWA Takio
School of Veterinary Medicine, Rakuno Gakuen University
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HIRAGA Takeo
School of Veterinary Medicine, Rakuno Gakuen University
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TERAOKA Hiroki
School of Veterinary Medicine, Rakuno Gakuen University
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UNO Yasuhiro
Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories
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KAWAKAMI Kei
School of Veterinary Medicine, Rakuno Gakuen University
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KOYAMA Fumika
School of Veterinary Medicine, Rakuno Gakuen University
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ASAKURA Hiroyuki
School of Veterinary Medicine, Rakuno Gakuen University
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