Deuterium Oxide's Effect on Defective Vestibulocochlear System in Mutant Bustling (BUS) Mice

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The bustling mouse (BUS/Idr: bus) is a mutant mouse strain which displays several behavioral abnormalities: hyperkinesia, circling, head tilting, and head bobbing. This phenotype develops in homozygous (bus/bus) mice progressively after birth and has been shown from cross experiments to be inherited by a single autosomal recessive gene. The effect of deuterium oxide, which has been shown to influence vestibular function, on abnormal behavior was examined in homozygous mice of different ages. Using light and electron microscopy, we also examined the development of pathological changes in the inner ears of homozygous mice. The pathological changes seen in the inner ears were: impairment and/or loss of auditory hair cells, deformity and/or loss of the inner and outer tunnels of the organ of Corti, hypoplasia of otoliths, and decreased numbers of neurons in the spiral ganglion. These abnormalities were present in homozygous mice before weaning and progressed thereafter, but were not seen in heterozygous (bus/+) mice. Although histological changes were also noted in the crista ampullaris and maculae, they were less prominent than in the cochlea, at least until six weeks of age. The oral administration of deuterated physiological saline (8-16 mg/kg) tended to reduce the abnormal behavior of homozygous mice, including rapid circling. These morphological and functional findings suggest that BUS mice may be a useful model for the analysis of the pathogenesis and treatment of vestibulocochlear disorders.
日本めまい平衡医学会の論文

Deuterium Oxide's Effect on Defective Vestibulocochlear System in Mutant Bustling (BUS) Mice

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