In Vitro Effects of Recombinant Human IL-11 on Human Malignant Lymphoma Cells

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概要

• 論文の詳細を見る

• IL-11 is a cytokine considered to have potential for the treatment of thrombocytopenia patients undergoing chemotherapy. The administered dose of IL-11 must not facilitate growth of malignant cells in addition to its thrombopoietic effect. In this study we focused on malignant lymphoma (ML), in which thrombocytopenia is a common adverse effect of chemotherapy. Cells obtained from biopsied lymph nodes of 7 patients were cultured with and without recombinant human IL-11 (rhIL-11). Cells growth was analyzed by the MTT assay. rhIL-11 did not enhance the proliferation of the lymphoma cells at any concentration. We believe that rhIL-11 is an expected agent for ML patients by the potential to reduce chemotherapy-induced thrombocytopenia.

• 日本リンパ網内系学会の論文
• 2002-10-01

著者

• MURATE Takashi

  Nagoya University School of Health Sciences

• NAGAI Hirokazu

  Department of Clinical Research, Nagoya National Hospital

• SAITO Hidehiko

  Nagoya Central Hospital

• Kobayashi Tohru

  Department Of Hematology And Oncology Nagoya University Graduate School Of Medicine

• Taniwaki M

  Kyoto Prefectural Univ. Medicine Kyoto

• KINOSHITA Tomohiro

  First Department of Internal Medicine, Nagoya University School of Medicine

• Saito Hidehiko

  First Department Of Internal Medicine Nagoya University School Of Medicine

• Saito Hidehiko

  Nagoya National Hospital

• Asano Haruhiko

  First Department Of Internal Medicine Nagoya University School Of Medicine

• MORI Naoyoshi

  First Division of Pathology, Nagoya University School of Medicine

• Tsukasaki Kunihiro

  Department Of Hematology And Oncology Nagoya University Graduate School Of Medicine

• HATANO Sonoko

  First Department of Internal Medicine, Nagoya University School of Medicine

• NAGAI Hirokazu

  Nagoya National Hospital

• KAWASHIMA Kouhei

  Department of Clinical Laboratory, Nagoya University Hospital

• Nagai Hirokazu

  Nagoya Medical Center Nagoya Jpn

• Nagai H

  First Department Of Internal Medicine Nagoya University School Of Medicine

• Nagai Hirokazu

  Department Of Clinical Research Nagoya National Hospital

• Mori Naoyoshi

  First Department Of Pathology Nagoya University School Of Medicine

• Kinoshita T

  Department Of Hematology And Oncology Nagoya University Graduate School Of Medicine

• Kinoshita Tomohiro

  First Department Of Internal Medicine Nagoya University School Of Medicine

• Kurokawa T

  First Department Of Internal Medicine Nagoya University School Of Medicine

• Murate Takashi

  First Department Of Internal Medicine Nagoya University School Of Medicine

• Hatano Sonoko

  First Department Of Internal Medicine Nagoya University School Of Medicine

• Takeyama K

  National Cancer Center Hospital Tokyo Jpn

• Murate Takashi

  Nagoya Univ. School Of Health Sci. Nagoya Jpn

• Kawashima Kouhei

  Department Of Clinical Laboratory Nagoya University Hospital

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