A case of κ type IgG multiple myeloma associated with the anti-HBs antibody activity

概要

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A case of female patient of 64 years old with κ type IgG multiple myeloma was reported. She showed the positive anti-HBs antibody. Her IgG was fractionated by Na2SO4 precipitation and following DEAE columnchromatography. After the confirmation that the above fractionated IgG reacted with only anti-κ serum, her IgG fractions were digested with pepsin to obtain F (ab')2 and Fc'. It has been demonstrated by the passive hemagglutination test that the F (ab')2 fragments bind HBs antigens and Fc' fragment did not bind HBs antigens. Her suppressor T cells were markedly increasted.
日本臨床免疫学会の論文