Auto-immune Pancytopenia

概要

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Immunological studies were carried out on ten patients with the aplastic anemia with hyperplasia of erythroblasts (AAHE). A decrease of E-RFC and Thy+ cells and an increase of Fc (γ) receptor positive (FcR+) cells, Tγ, Tpμ and null lymphocytes were demonstrated in blood lymphocytes of patients with AAHE. Tγ, FcR+ cells and K cells were increased in the bone marrow lymphocytes subpopulation in patients with AAHE. The antibody dependent cell-mediated cytotoxity to patelets, erythroblasts and immature granulocytes was positive in patients with AAHE. Bone marrow lymphocytes from patients with AAHE produced IgG in vitro by the stimulation of platelet membrane antigens, erythroblast membrane antigens and immature granulocyte membrane antigens. A decrease of suppressor T cells (Ts) was present in blood lymphocytes of patients with AAHE. The in vitro development to Ig producing cells of bone marrow lymphocytes by PWM stimulations was increased in AAHE. The sensitivity of bone marrow lymphocytes to normal Ts was decreased in AAHE. These results indicate that AAHE is the autoimmune diseases which might be cause probably by the similar mechanism with that in Hashimoto's thyroidits. AAHE should be termed as the autoimmune pancytopenia.
日本臨床免疫学会の論文