Detecting circulating immune complex in the sera of patients with connective tissue diseases by the 125I-protein A-PEG procedure

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概要

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• Levels of circulating immune complexes in the serum of patients with connective tissue diseases were measured by the 125I-protein A-PEG procedure. These included 21 patients with systemic lupus erythematosus (SLE), 20 rheumatic arthritis (RA), 11 sicca syndrome (SS), 9 progressive systemic scherosis (PSS), 9 mixed connective tissue diseases (MCTD) and 10 healthy individuals. The groups of connective tissue diseases except for SS had increased levels of immune complexes in serum compared to a group of healthy individuals. In particular, patients with SLE and RA were high levels of immune complexes. No correlation was found between the levels of circulating immune complexes and serum complement (CH50, C3 and C4). Also, there was no correlation with the titers of IgM-rheumatoid factor in the sera of patients with seropositive RA.125I-protein A-PEG procedure is a sensitive, simple and not complement dependent.

• 日本臨床免疫学会の論文

著者

• 蔵 和夫

  埼玉医科大学第1内科

• 荒尾 俊夫

  埼玉医科大学第1内科

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• Detecting circulating immune complex in the sera of patients with connective tissue diseases by the 125I-protein A-PEG procedure

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