Distinct specifity of lymphocytotoxic antibodies in autoimmune disease

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Lymphocytotoxic antibodies are demonstrated with high incidence in the sera of patients with autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis and myasthenia gravis.The present report describes biologic characteristics of the antibodies found in these autoimmune diseases. Lymphocytotoxic antibodies were first proved to be specific for T lymphocytes and their specificity against human T cell subsets was thus investigated. IgG-Fc receptor bearing cells (Tγ cells) were separated from Tγ-depleted cells (Tnon-γ cells) according to the former capacity to form rosettes with ox red blood cells sensitized by IgG antibodies. Lymphocytotoxic antibodies obtained from the sera of patients with SLE killed mostly Tγ cells, while those from rheumatoid arthritis and myasthenia gravis showed a preferential reactivity against Tnon-γ cells.After in vitro allosensitization, specific allogeneic cell-mediated lympholysis mediated by human peripheral blood lymphocytes. When normal T lymphocytes were pretreated with complement and the sera containing lymphocytotoxic antibodies before mixed lymphocyte reaction, the killer cell activity was augumented in cases with SLE and rheumatoid arthritis. Then the effects of lymphocytotoxic antibodies on killer T cells in cell-mediated lympholysis were investigated. The sera from patients with SLE and myasthenia gravis significantly suppressed cytolytic activity but those with rheumatoid arthritis showed no influence.It was suggested that lymphocytotoxic antibodies in the patients with SLE, rheumatoid arthritis and myasthenia gravis were reactive preferentially with distinct T cell subsets.

Distinct specifity of lymphocytotoxic antibodies in autoimmune disease

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