Effect of Trimebutine on Contractile Responses in Skinned Ileal Smooth Muscle.
スポンサーリンク
概要
- 論文の詳細を見る
The effects of trimebutine on Ca<SUP>2+</SUP> release and modulation of Ca<SUP>2+</SUP> sensitivity of contractile elements induced by carbachol (CCh) were investigated using a tension measuring method in β-escin-treated skinned smooth muscle of the longitudinal muscle layer of guinea pig ileum. Trimebutine (10-100 μM) concentration-dependently inhibited tension development brought about by Ca<SUP>2+</SUP> release from intracellular stores induced by CCh (10 μM), but did not affect those induced by inositol 1, 4, 5-trisphosphate (IP<SUB>3</SUB>, 25 μM) or caffeine (5 mM). The inhibitory effect was reversible. Trimebutine (100 μM) neither altered the Ca<SUP>2+</SUP> sensitivity of the contractile elements nor affected the effects of GTPγS (50 <SUP>2+</SUP>M) and CCh (100 <SUP>2+</SUP>M) in potentiating Ca<SUP>2+</SUP> sensitivity of the contractile elements after the Ca<SUP>2+</SUP> storage function had been eliminated by A23187. These results suggest that trimebutine inhibits CCh-induced Ca<SUP>2+</SUP> release by acting at some point during the coupling of muscarinic receptors through a G-protein to phospholipase C and thus reducing the accumulation of IP<SUB>3</SUB>.
- 公益社団法人 日本薬理学会の論文
著者
-
Komori Seiichi
Laboratory Of Pharmacology Department Of Veterinary Medicine Faculty Of Agriculture United Graduate
-
Ohashi Hidenori
Laboratory Of Pharmacology Department Of Veterinary Medicine Faculty Of Agriculture United Graduate
-
Itagaki Mitsue
Laboratory Of Pharmacology Department Of Veterinary Science Faculty Of Agiculture Gifu University
-
Nagasaki Masaaki
Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.
関連論文
- Muscarinic Receptor Subtypes Mediating Ca2+ Sensitization of Intestinal Smooth Muscle Contraction: Studies with Receptor Knockout Mice
- Nitrergic Inhibition of Tachykininergic Neuro-Muscular Transmission via Cyclic GMP in the Hamster Ileum
- Long-Lasting Anti-emetic Effect of T-2328, a Novel NK_1 Antagonist
- Pharmacological Characterization of T-2328, 2-Fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile Dihydrochloride, as a Brain-Penetrating Antagonist of Tachykinin NK_1 Receptor
- Characterization of Muscarinic Receptor-Mediated Cationic Currents in Longitudinal Smooth Muscle Cells of Mouse Small Intestine
- Phospholipase C Involvement in Activation of the Muscarinic Receptor-Operated Cationic Current in Guinea Pig Ileal Smooth Muscle Cells
- Effects of Cholecystokinin (CCK)-JMV-180 on the CCK Receptors of Rabbit Pancreatic Acini and Gallbladder Smooth Muscle
- A Smooth Muscle Excitatory Material from the Nerve of Remak of the Chicken Rectum
- Role of Ca^ Mobilization in Muscarinic Receptor-Mediated Membrane Depolarization in Guinea Pig Ileal Smooth Muscle Cells
- M2 and M3 Muscarinic Receptors Couple, Respectively, With Activation of Nonselective Cationic Channels and Potassium Channels in Intestinal Smooth Muscle Cells
- Possible Involvement of a Small G-Protein Sensitive to Exoenzyme C3 of Clostridium botulinum in the Regulation of Myofilament Ca^ Sensitivity in β-Escin Skinned Smooth Muscle of Guinea Pig Ileum
- Pharmacological Characterization of T-2328, 2-Fluoro-4-methoxy-3-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1-biphenyl]-4-carbonitrile Dihydrochloride, as a Brain-Penetrating Antagonist of Tachykinin NK1 Receptor
- Evidence for M2 and M3 Muscarinic Receptor Involvement in Cholinergic Excitatory Junction Potentials Through Synergistic Activation of Cation Channels in the Longitudinal Muscle of Mouse Ileum
- Effect of Trimebutine on Contractile Responses in Skinned Ileal Smooth Muscle.
- Smooth muscle excitatory substances from Remak nerve of the chicken and a comparison of their pharmacological and chemical properties with substance P.
- Phospholipase C Involvement in Activation of the Muscarinic Receptor-Operated Cationic Current in Guinea Pig Ileal Smooth Muscle Cells
- Stimulative Effect of Sodium Nitroprusside on Peristaltic Reflex in Isolated Guinea Pig Ileal Segments.
- Contractile Responses to Histamine and GTP.GAMMA.S in .BETA.-Escin-Treated Skinned Smooth Muscle of Guinea Pig Ileum.
- Evidence for M_2 and M_3 Muscarinic Receptor Involvement in Cholinergic Excitatory Junction Potentials Through Synergistic Activation of Cation Channels in the Longitudinal Muscle of Mouse Ileum