M2 and M3 Muscarinic Receptors Couple, Respectively, With Activation of Nonselective Cationic Channels and Potassium Channels in Intestinal Smooth Muscle Cells
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概要
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Smooth muscle cells of guinea pig ileum express both M2 and M3 subtypes of muscarinic receptors. Under voltage clamp, activation of the muscarinic receptors with carbachol (CCh) induces Ca2+-activated K+ current (IK-Ca) and nonselective cationic current (Icat). Receptor subtypes mediating the current responses were characterized by using pirenzepine, AF-DX116, 4-DAMP and atropine, which have different profiles of the affinity constants for muscarinic receptor subtypes. The muscarinic antagonists inhibited either CCh-evoked IK-Ca or Icat with different potencies. Their relative potencies for IK-Ca and Icat inhibition resembled the relative affinity constants for M3 and M2 subtypes, respectively. Thus, the IK-Ca is mediated via the M3 subtype and the Icat via the M2 subtype.
- 社団法人 日本薬理学会の論文
著者
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UNNO Toshihiro
Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biologi
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KOMORI Seiichi
Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biologi
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Komori Seiichi
Department Of Pathogenetic Veterinary Science The United Graduate School Of Veterinary Sciences Gifu
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Komori S
Gifu Univ. Gifu Jpn
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Unno T
Gifu Univ. Gifu Jpn
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Unno Toshihiro
Department Of Pathogenic Veterinary Science United Graduate School Of Veterinary Science Gifu Univer
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Komori Seiichi
Laboratory Of Pharmacology Department Of Veterinary Medicine Faculty Of Agriculture United Graduate
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Unno Toshihiro
Laboratory Of Pharmacology Department Of Veterinary Medicine Faculty Of Agriculture United Graduate
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OHASHI Hidenori
Laboratory of Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, United Gradua
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NAKAYAMA Takahisa
Laboratory of Pharmacology, Department of Veterinary Science, Faculty of Agriculture, Gifu Universit
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Ohashi Hidenori
Laboratory Of Pharmacology Department Of Veterinary Medicine Faculty Of Agriculture United Graduate
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Nakayama Takahisa
Laboratory Of Pharmacology Department Of Veterinary Science Faculty Of Agriculture Gifu University
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