Inhibitory Effects of Hyaluronan on (14C)Arachidonic Acid Release from Labeled Human Synovial Fibroblasts.
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概要
- 論文の詳細を見る
The effects of hyaluronan (HA) on the release of arachidonic acid (AA) from phospholipids induced by bradykinin in synovial fibroblasts of osteoarthritic patients were examined. HA inhibited [<SUP>14</SUP>C]AA release from prelabeled synovial cells stimulated with and without bradykinin 1 hr after incubation with HA and thereafter. The inhibitory effects of HA on [<SUP>14</SUP>C]AA release were dependent on the concentration and molecular weight of HA. However, inhibition of [<SUP>14</SUP>C]AA release by HA was not merely due to the viscosity of HA. The [<SUP>14</SUP>C]AA release induced by calcium-ionophore A23187 was also inhibited by HA with a high molecular weight. In addition, HA did not affect [<SUP>14</SUP>C]AA uptake by the cells. Our results suggest that HA with a high molecular weight elicits anti-inflammatory effects, at least in part, by inhibiting AA release in inflamed joints.
- 公益社団法人 日本薬理学会の論文
著者
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TOBETTO Kenji
Research & Development Laboratories, Maruho Co.,Ltd.
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Shinogi Masaki
Department Of Radiopharmacy Kobe Pharmaceutical University
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Ando Takao
Research Institute Of Electronics Shizuoka University
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Tobetto Kenji
Research Laboratories, Maruho Co., Ltd.
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Yasui Tadashi
Research Laboratories, Maruho Co., Ltd.
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Hayaishi Masahiro
Hayaishi Hospital
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Motohashi Noriko
Department of Radiopharmaceutical Chemistry, Kobe Women''s College of Pharmacy
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Mori Itsuhiko
Department of Radiopharmaceutical Chemistry, Kobe Women''s College of Pharmacy
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Mori Itsuhiko
Department of Radiopharmaceutical Chemistry, Kobe Women''s College of Pharmacy
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Motohashi Noriko
Department of Radiopharmaceutical Chemistry, Kobe Women''s College of Pharmacy
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Shinogi Masaki
Department of Radiopharmaceutical Chemistry, Kobe Women''s College of Pharmacy
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- Inhibitory Effects of Hyaluronan on (14C)Arachidonic Acid Release from Labeled Human Synovial Fibroblasts.