EFFECTS OF CYTOPLASMIC AND MICROSOMAL FRACTIONS ON ATP-Mg<SUP>++</SUP> STIMULATED CATECHOLAMINE RELEASE FROM ISOLATED ADRENOMEDULLARY GRANULES
スポンサーリンク
概要
- 論文の詳細を見る
There is evidence that Ca<SUP>++</SUP> is required for the release of catecholamine from the adrenal medulla evoked by acetylcholine or a high K<SUP>+</SUP> concentration (1, 2) and that an increased influx of Ca<SUP>++</SUP> into the cell occurs during this process (3). It has therefore been proposed that it is the entry of Ca<SUP>++</SUP> into the cell which somehow triggers the secretory process (4, 5). On the other hand, the release of catecholamine from isolated catecholamine storage granules is shown to be stimulated by ATP and Mg<SUP>++</SUP> (6-8) and this ATP-Mg<SUP>++</SUP> stimulated release of catecholamine also requires a low concentration of Ca<SUP>++</SUP> (<10<SUP>-5</SUP>M), present as a contaminant in the reaction mixture (9). The authors suggested that ATP-Mg<SUP>++</SUP> stimulated release of catecholamine from the granules could be a step in the secretory response of the adrenal medulla.<BR> To elucidate the exact intracellular mechanism of adrenal medullary secretion, it is necessary to determine whether or not intracellular elements other than catecholamine storage granules are involved in the regulation of catecholamine release from the granules. We have investigated the effects of the cytoplasmic and microsomal fractions on ATP-Mg<SUP>++</SUP> stimulated catecholamine release from the granules. Results suggest that these two fractions are important in regulation of catecholamine release from the adrenal medulla.
- 公益社団法人 日本薬理学会の論文
著者
-
Izumi Futoshi
Department Of Pharmacology School Of Medicine University Of Occupational And Environmental Health
-
Kashimoto Takeshi
Department Of Pharmacology Ii Osaka University School Of Medicine
-
OKA Motoo
Department of Pharmacology II, Osaka University School of Medicine
-
IZUMI Futoshi
Department of Pharmacology II, Osaka University School of Medicine
関連論文
- Ursodeoxycholic acid inhibits histamine release from rat peritoneal mast cells
- Stimulatory Effect of Interleukin-1α on Proliferation through a Ca^/Calmodulin dependent Pathway of a Human Thyroid Carcinoma Cell Line, NIM 1
- β ADRENERGIC TRANSMISSION AND EFFECTS OF β ADRENORECEPTOR BLOCKADES IN PATIENTS WITH NEURALLY MEDIATED SYNCOPE
- Propofol Inhibits Muscarinic Acetylcholine Receptor-Mediated Signal Transduction in Xenopus Oocytes Expressing the Rat M1 Receptor
- EFFECTS OF CLASS I ANTIARRHYTHMIC DRUGS ON ADRENOCEPTORS IN CULTURED RAT CARDIOCYTES
- STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTIBIOTIC PEPTIDES WHICH CAUSE Ca^-DEPENDENT CATECHOLAMINE RELEASE
- ISOLATION AND STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTIBIOTIC PEPTIDES, TRICHOSPORIN-Bs, WHICH CAUSE Ca^-DEPENDENT CATECHOLAMINE RELEASE FROM ADRENAL MEDULLARY CHROMAFFIN CELLS
- Effect of cAMP-Dependent Protein Kinase on Catecholamine Secretion from Bovine Adrenal Chromaffin Cells
- THE PHARMACOLOGICAL ACTION OF PUROTHIONIN (The 6th Meeting for the Study of Toxic Effect)
- Functional Consequences of Substitution of the Disulfide-Bonded Segment, Cys127-Cys150, Located in the Extracellular Domain of the Na, K-ATPase β Subunit: Arg148 Is Essential for the Functional Expression of Na, K-ATPase