ROLE OF CALCIUM FOR MAGNESIUM-ACTIVATED ADENOSINETRIPHOSPHATASE ACTIVITY AND ADENOSINETRIPHOSPHATE-MAGNESIUM STIMULATED CATECHOLAMINE RELEASE FROM ADRENAL MEDULLARY GRANULES
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概要
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There have been several reports that Mg<SUP>++</SUP>-activated ATPase is present in the catecholamine storage granules of the adrenal medulla (1-3) and that this ATPase may be linked in some way with the ATP-Mg<SUP>++</SUP> stimulated uptake and release of catecholamine by isolated granules (4-9).<BR> Recently, we found that the low concentration of Ca<SUP>++</SUP> present in the incubation medium as a contaminant participated in the release of catecholamine from the granules stimulated by ATP and Mg<SUP>++</SUP> (10). This finding is interesting in relation to the fact that acetylcholine or excess potassium causes the release of catecholamine from a perfused adrenal gland by promoting increased uptake of Ca<SUP>++</SUP> into the cells (11-13).<BR> This paper reports investigations on the effect of Ca<SUP>++</SUP> on the Mg<SUP>++</SUP>-activated ATPase activity in isolated catecholamine storage granules from the adrenal medulla. The possible relationship of these results to the release of catecholamine from the granules is discussed.
- 社団法人 日本薬理学会の論文
著者
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Izumi Futoshi
Department Of Pharmacology School Of Medicine University Of Occupational And Environmental Health
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Kashimoto Takeshi
Department Of Pharmacology Ii Osaka University School Of Medicine
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OKA Motoo
Department of Pharmacology II, Osaka University School of Medicine
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IZUMI Futoshi
Department of Pharmacology II, Osaka University School of Medicine
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