MECHANISM OF 5-HYDROXYTRYPTAMINE RELEASE INDUCED BY BACTERIAL LIPOPOLYSACCHARIDE FROM BLOOD PLATELETS : I. A POSSIBLE PARTICIPATION OF PROTEOLYTIC ENZYME IN PLASMA
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概要
- 論文の詳細を見る
Recently it was shown by Kuruma <I>et al</I>. (1) and Takagi and Kuruma (2) that a single injection of bacterial pyrogenic lipopolysaccharide (LPS) into rabbit caused a marked reduction of 5-hydroxytryptamine (5-HT) content in brain stem and spleen, without affecting on the content of noradrenaline and the time course of 5-HT decrease in brain stem is closely correspond with that of rise in rectal temperature. This observation prompted us to study the mechanism of 5-HT release induced by LPS using platelet since it has been shown that the use of platelets is a valuable experimental procedure for study of the 5-HT release mechanism (3). Although 5-HT releasing effect of LPS on platelet has been reported previously by Shimamoto <I>et al</I>. (4, 5), Des Prez (6-8) and Davis <I>el al</I>. (9, 10), its mechanism is remains to be investigated.
- 社団法人 日本薬理学会の論文
著者
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野村 靖幸
Department of Pharmacological Science, Hokkaido University
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車 勇
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
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高木 博司
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
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高木 博司
Department of Pharmacology, Faculty of Pharmaceutical Sciences Kyoto University
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野村 靖幸
Department of Pharmacology, Faculty of Pharmaceutical Sciences Kyoto University
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車 勇
Department of Pharmacology, Faculty of Pharmaceutical Sciences Kyoto University
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