ANTAGONISM BY TETRABENAZINE OF THE DEPRESSIVE EFFECTS OF MORPHINE ON THE CENTRAL NERVOUS SYSTEM
スポンサーリンク
概要
- 論文の詳細を見る
The authors have reported in the previous papers that tetrabenazine antagonizes morphine analgesia in mice (1) and that it has depressive effects on some afferent pathways in the central nervous system in rabbits and cats, like those of morphine (2).<BR> The questions arise whether the antagonistic effect by tetrabenazine of the central effects of morphine can be recognized in other species besides mice, whether all of the depressive actions of morphine on the afferent pathways of the central nervous system are suppressed by the tetrabenazine pretreatment, and whether tetrabenazine may owe its antagonistic action against morphine to its ability to deplete the catecholamines and serotonin levels in the brain.<BR> The purpose of this study was to investigate these questions using the electrophysiological techniques.
- 公益社団法人 日本薬理学会の論文
著者
-
高木 博司
Department of Pharmacology, Faculty of Pharmaceutical Sciences Kyoto University
-
石田 柳一
Osaka Research Laboratory, Tanabe Seiyaku Co. Ltd.
関連論文
- MECHANISM OF 5-HYDROXYTRYPTAMINE RELEASE INDUCED BY BACTERIAL LIPOPOLYSACCHARIDE FROM BLOOD PLATELETS : II. COMPARISON OF MORPHOLOGICAL CHANGES IN PLATELETS INDUCED BY VARIOUS RELEASERS
- MECHANISM OF 5-HYDROXYTRYPTAMINE RELEASE INDUCED BY BACTERIAL LIPOPOLYSACCHARIDE FROM BLOOD PLATELETS : I. A POSSIBLE PARTICIPATION OF PROTEOLYTIC ENZYME IN PLASMA
- STUDIES ON THE MECHANISM OF ACTION OF TETRABENAZINE AS A MORPHINE ANTAGONIST : II. A PARTICIPATION OF CATECHOLAMINE IN THE ANTAGONISM
- EFFECTS OF SEVERAL ANTICHOLINERGIC DRUGS ON THE POST-TETANIC POTENTIATION IN THE PHRENIC NERVE-DIAPHRAGM PREPARATION OF THE RAT
- EFFECTS OF CHANGES IN TEMPERATURE AND IONIC ENVIRONMENT ON THE POST-TETANIC POTENTIATION IN THE PHRENIC NERVE-DIAPHRAGM PREPARATION OF THE RAT
- A POSSIBLE MECHANISM OF ARRHYTHMIA INDUCED BY 1-ADAMANTANAMINE
- THE EFFECTS OF SOME DRUGS ON THE POST-TETANIC POTENTIATION (PTP) AT THE NEUROMUSCULAR JUNCTION OF THE ISOLATED PHRENIC NERVE-DIAPHRAGM PREPARATION OF THE RAT
- ELECTROENCEPHALOGRAPHIC STUDIES ON MORPHINE DEPENDENCE IN RAT
- A MODIFICATION OF HAFFNER'S METHOD FOR TESTING ANALGESICS
- ANTAGONISM BY TETRABENAZINE OF THE DEPRESSIVE EFFECTS OF MORPHINE ON THE CENTRAL NERVOUS SYSTEM
- ELECTROENCEPHALOGRAPHIC STUDIES ON MORPHINE DEPENDENCE IN RABBIT
- EFFECT OF BACTERIAL LIPOPOLYSACCHARIDE ON THE CONTENT OF SEROTONIN AND NOREPINEPHRINE IN RABBIT BRAIN