A MODIFICATION OF HAFFNER'S METHOD FOR TESTING ANALGESICS
スポンサーリンク
概要
- 論文の詳細を見る
Haffner's tail-pinch method (1) for testing analgesic drugs has been adopted in many laboratories either in the original method (2-4, 17) or in the varieties of modifications (5-7). Certain objections can, however, be raised against the use of the Haffner's method; the intensity of the painful stimulus produced by this method is not shown in figures, neither is it varied quantitatively.<BR> The improvement of these disadvantages has been carried out by Eddy (8), Friend and Harris (9), Fleish and Dolivo (10), Brodie <I>et al</I>. (11), Green and Young (12), Yanai (13), Takagi and Kameyama (14), and so on, but there seems still no ideal method exists.<BR> The Authors discribe here a simple tail-pinch method, which the intensity of pressure stimulus is varied quantitatively and which satisfies the sensitivity and reproducibility for testing non-narcotic analgesics as well as narcotics.
- 公益社団法人 日本薬理学会の論文
著者
-
高木 博司
Department of Pharmacology, Faculty of Pharmaceutical Sciences Kyoto University
-
中間 元隆
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
-
犬飼 利也
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University
関連論文
- MECHANISM OF 5-HYDROXYTRYPTAMINE RELEASE INDUCED BY BACTERIAL LIPOPOLYSACCHARIDE FROM BLOOD PLATELETS : II. COMPARISON OF MORPHOLOGICAL CHANGES IN PLATELETS INDUCED BY VARIOUS RELEASERS
- MECHANISM OF 5-HYDROXYTRYPTAMINE RELEASE INDUCED BY BACTERIAL LIPOPOLYSACCHARIDE FROM BLOOD PLATELETS : I. A POSSIBLE PARTICIPATION OF PROTEOLYTIC ENZYME IN PLASMA
- STUDIES ON THE MECHANISM OF ACTION OF TETRABENAZINE AS A MORPHINE ANTAGONIST : II. A PARTICIPATION OF CATECHOLAMINE IN THE ANTAGONISM
- EFFECTS OF SEVERAL ANTICHOLINERGIC DRUGS ON THE POST-TETANIC POTENTIATION IN THE PHRENIC NERVE-DIAPHRAGM PREPARATION OF THE RAT
- EFFECTS OF CHANGES IN TEMPERATURE AND IONIC ENVIRONMENT ON THE POST-TETANIC POTENTIATION IN THE PHRENIC NERVE-DIAPHRAGM PREPARATION OF THE RAT
- A POSSIBLE MECHANISM OF ARRHYTHMIA INDUCED BY 1-ADAMANTANAMINE
- THE EFFECTS OF SOME DRUGS ON THE POST-TETANIC POTENTIATION (PTP) AT THE NEUROMUSCULAR JUNCTION OF THE ISOLATED PHRENIC NERVE-DIAPHRAGM PREPARATION OF THE RAT
- ELECTROENCEPHALOGRAPHIC STUDIES ON MORPHINE DEPENDENCE IN RAT
- A MODIFICATION OF HAFFNER'S METHOD FOR TESTING ANALGESICS
- ANTAGONISM BY TETRABENAZINE OF THE DEPRESSIVE EFFECTS OF MORPHINE ON THE CENTRAL NERVOUS SYSTEM
- ELECTROENCEPHALOGRAPHIC STUDIES ON MORPHINE DEPENDENCE IN RABBIT
- EFFECT OF BACTERIAL LIPOPOLYSACCHARIDE ON THE CONTENT OF SEROTONIN AND NOREPINEPHRINE IN RABBIT BRAIN
- POTENTIATION BY NALORPHINE OF THE ANALGESIC EFFECT OF AMINOPYRINE AND ANTIPYRINE