EFFECT OF 8-SUBSTITUTED CYCLIC AMP DERIVATIVES ON SOLUBLE GUANYLATE CYCLASE ACTIVITY FROM HUMAN PLATELETS
スポンサーリンク
概要
- 論文の詳細を見る
Inhibitory effect of 8-alkyl cyclic AMP derivatives on the soluble guanylate cyclase activity from human platelets was investigated. Cyclic AMP derivatives with alkyl chains of 6 or less carbons at 8-position of the purine base were not inhibitory, but the derivatives with alkyl chains of 7 or more carbons produced significant inhibition of the soluble guanylate cyclase activity. The extent of inhibitory effect increased when a longer alkyl chain was introduced at the 8-position of cyclic AMP. In contrast, 8-alkyl adenosine derivatives did not inhibit the cyclase activity. These results suggest that the platelet guanylate cyclase has an affinity for cyclic AMP derivatives with hydrophobic property as well as for several guanine nucleotides such as GTP or cyclic GMP.
- 社団法人 日本薬理学会の論文
著者
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佐々木 泰治
旭化成工業ライフサイエンス総合研究所
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Hidaka Hiroyoshi
Department Of Pharmacology Nagoya University School Of Medicine
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Sasaki Yasuharu
Institute Of Life Science Asahi Chemical Industry Co. Ltd.
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Sasaki Yasuharu
Life Science Research Center Asahi Chemical Industry Co. Ltd.
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SASAKI Yasuharu
Biochemical Research Center Pharmaceutical Plant, Asahi Chemical Ind. Co., Ltd.
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IKUKAWA Sachiko
Department of Pharmacology, Mie University School of Medicine
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Hidaka Hiroyoshi
Department Of Pharmacology Mie University
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HIDAKA Hiroyoshi
Department of Biochemistry, Institute for Developmental Research, Aichi Prefecture Colony
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