Effect of timiperone, a new antipsychotic drug, on the sleep-wakefulness cycle in cats.
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概要
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The effect of timiperone, a new antipsychotic drug, on the sleepwakefulness cycle in cats was assessed by EEG, EMG and eye movement potential. Timiperone (0.03 to 0.3 mg/kg, i.p.) dose-dependently increased the slow wave sleep (SWS) time and decreased the paradoxical sleep (PS) time. Further, the onset of the first period of PS was delayed, and the number of PS phases tended to he decreased after the 0.3 mg/ kg dose. These results suggest that the neurological control of the cerebral dopaminergic system might be at least in part attributable to the effect of timiperone on sleep mechanisms.
- 公益社団法人 日本薬理学会の論文
著者
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TANAKA Makoto
Laboratory of Advanced Science and Technology for Industry, University of Hyogo
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Kojima Hiroshi
Laboratory of Plant Physiology, Biological Institute, Faculty of Science, Nagoya University
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Akashi Akira
Laboratory Of Chemistry And Technology Of Animal Products Faculty Of Agriculture Kyushu University
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TANAKA Makoto
Laboratory of Pharmacology, Research Institute, Daiichi Seiyaku Co., Ltd.
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AKASHI Akira
Laboratory of Pharmacology, Research Institute, Daiichi Seiyaku Co., Ltd.
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