Effects of N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384) on learning and memory in rats.
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概要
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Effects of N-(2, 6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384) on learning and memory were studied using four different experimental rat models. In electroconvulsive shock- or scopolamine-induced amnesia in the step-through passive avoidance task, DM-9384 improved both types of amnesia when administered before the training trial. Aniracetam also showed similar but somewhat weaker effects. Furthermore, in the scopolamine amnesia mode!, an improvement was confirmed with arecoline. The dose-response curves for these compounds were bell-shaped. In the shuttle box active avoidance task, DM-9384 administered daily 1 hr before each training session facilitated the acquisition process of the avoidance response. In addition, the experiment of light-dark discrimination task with positive reinforcement showed that this compound administered daily after each session slightly accelerated the acquisition process of the correct response. These results suggest an ability of DM-9384 to enhance cognitive functions.
- 公益社団法人 日本薬理学会の論文
著者
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Kojima Hiroshi
Laboratory of Plant Physiology, Biological Institute, Faculty of Science, Nagoya University
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Akashi Akira
Laboratory Of Chemistry And Technology Of Animal Products Faculty Of Agriculture Kyushu University
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OJIMA Hisayuki
Laboratory of Pharmacology, Research Institute, Daiichi Seiyaku Co., Ltd.
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SAKURAI Takeo
Laboratory of Pharmacology, Research Institute, Daiichi Seiyaku Co., Ltd.
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YAMASAKI Terukiyo
Laboratory of Pharmacology, Research Institute, Daiichi Seiyaku Co., Ltd.
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