Pharmacological study of TA-0910, a new thyrotropin-releasing hormone(TRH) analog. (IV). Effects on experimental memory impairment in mice and rats.

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of a new TRH analog, TA-0910, orally administered, on experimental memory impairments for the one-trial passive avoidance response in anoxic mice (light-dark box), active avoidance response in basal forebrain (BF)-lesioned rats (shuttle box), and delayed alternation task in scopolamine-treated rats (T-maze) were studied. In mice, TA-0910 (3-30 mg) administered 60 min before the retention trial dose-dependently prolonged the passive avoidance response latency reduced by CO<SUB>2</SUB>-exposure that was given immediately after the acquisition trial, but not when it was given 60 min before the acquisition or just after the anoxic treatment. In rats, TA-0910 (0.3-3 mg/kg) administered 40-60 min before the test trial, dose-dependently prevented the reduction in mean avoidance rate caused by BF-lesioning and elevated the scopolamine (0.1 mg/kg, i.p.)-induced reduction in percent correct choice level in the alternation task. TRH (30-300 mg/kg), on the other hand, produced no improvements in any of the above tests. These results suggest that TA-0910 improves impaired memory by correcting the retrieval process of memory.

• 公益社団法人 日本薬理学会の論文

著者

• Nakagawa Hiroyuki

  Department Of Applied Chemistry School Of Science And Engineering Waseda University

• Ishida Ryuichi

  Department Of Material-process Engineering And Applied Chemistry For Environment

• Kinoshita Kiyoshi

  Department of Pharmacology, Kyoritsu College of Pharmacy

• YAMAMURA Michio

  Department of Pharmacology, Safety Research Laboratory, Tanabe Seiyaku

関連論文

• Mucinous carcinoma of the breast with neuroendocrine differentiation
• Initial experience of using the filter protection device during carotid artery stenting in Japan
• Multiple cerebral aneurysms associated with Takayasu arteritis successfully treated with coil embolization
• Cerebral hemorrhage with angiographic extravasation immediately after carotid artery stenting
• Successful percutaneous transluminal angioplasty and stenting for symptomatic intracranial vertebral artery stenosis using intravascular ultrasound virtual histology
• Fast Fluid - Attenuated Inversion Recovery (FAST - FLAIR) of Ischemic Lesions in the Brain : Comparison with T2 - Weighted Turbo SE
• α-Anomer-Selective Glucosylation of (+)-Catechin by the Crude Enzyme, Showing Glucosyl Transfer Activity, of Xanthomonas campestris WU-9701
• α-Anomer-Selective Glucosylation of Menthol with High Yield through a Crystal Accumulation Reaction Using Lyophilized Cells of Xanthomonas campestris WU-9701
• Selective and Continuous Degradation of Carbazole Contained in Petroleum Oil by Resting Cells of Sphingomonas sp. CDH-7
• Purification and Characterization of a Novel β-Agarase from an Alkalophilic Bacterium, Alteromonas sp.E-1
• Anomer-Selective Glucosylation of l-Menthol by Yeast α-Glucosidase
• Anomer-Selective Glucosylation of l-Menthol Using Lyophilized Cells of Saccharomyces cerevisiae
• Anomer Selective Formation of l-Menthyl α-D-Glucopyranoside by α-Glucosidase-catalyzed Reaction
• Functional Analyses of a Neural Cell Specific Variant of Microtubule-Associated Protein 4
• Cerebellar hemorrhage after spine surgery
• Change of cross-linked telopeptide of type I collagen (ICTP) and other bone resorption markers in patients with bone fragility fractures
• Usefulness of White Blood Cell Differential for Early Diagnosis of Surgical Wound Infection Following Spinal Instrumentation Surgery
• Changes in total alkaline phosphatase level after hip fracture : comparison between femoral neck and trochanter fractures
• Median nerve entrapment at the volar stump of the proximal radial fragment in Colles' fracture
• Pseudoarthrosis of vertebral fracture : radiographic and characteristic clinical features and natural history
• Urinary excretion of type I collagen cross-linked N-telopeptide and serum bone-specific alkaline phosphatase analysis to determine the correlation of age and back-pain related changes in elderly women
• Changes in biochemical markers of bone in patients with insufficiency fractures
• Abducens nerve palsy as a rare complication of spinal surgery : a case report
• Dual-Gradient Capillary Electrochromatography by Varying the Mobile Phase Composition and Applied Voltage
• Effect of the Net Surface Charge Density of Heptakis-6-bromo-6-deoxy-β-cyclodextrin Bonded Silica Gels on the Retention Behaviors of Neutral Cresol Isomers in HPLC
• Flexible Foraging of Ants under Unsteadily Varying Environment(Cross-disciplinary Physics and Related Areas of Science and Technology)
• Identification of a Neural Cell Specific Variant of Microtubule-Associated Protein 4
• FUNCTION OF MICROTUBULE-ASSOCIATED PROTEIN 4 ISOFORMS, THE REPEAT REGION ORGANIZATIONS DIFFER FROM EACH OTHER(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• A UBIQUITOUSLY DISTRIBUTED MICROTUBULE-ASSOCIATED PROTEIN 4 (MAP4) EXPRESSES A NEURON-SPECIFIC ISOFORM(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
• 酸化亜鉛分散炭素材料の黄色ブドウ球菌に対する抗菌活性
• Fibroma of the Omentum Resembling an Ovarian Tumor in the Pelvis
• Unusual stress fracture of the femoral neck in a young adult not caused by excessive stress : a case report
• Nitric Oxide Underlies the Differentiation of PC12 Cells Induced by Depolarization with High KCI^1
• FUNCTIONAL ANALYSIS OF A NEURON-SPECIFIC MAP4 ISOFORM(Cell Biology and Morphology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
• Antibacterial Characteristic of Spherical Carbon Containing ZnO
• Aggregation of Partially Unfolded Myosin Subfragment-1 into Spherical Oligomers with Amyloid-Like Dye-Binding Properties
• Conversion of Tar in Hot Coke Oven Gas by Pyrolysis and Steam Reforming
• ANGIOTENSIN RECEPTOR BLOCKER CANDESARTAN BINDS TO AND UPREGULATES MOLECULAR CHAPERONE HSP90 IN THE HIPPOCAMPAL CA1 NEURONS ― A POSSIBLE MECHANISM OF NEUROPROTECTION BY ANGIOTENSIN RECEPTOR BLOCKER ―
• High-Performance Liquid Chromatographic Analysis of Polycyclic Aromatic Hydrocarbons Extracted by Blue-Cotton from River Waters (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
• A 260-kDa Filamin/ABP-Related Protein in Chicken Gizzard Smooth Muscle Cells Is a New Component of the Dense Plaques and Dense Bodies of Smooth Muscle
• Actin-filaments Localize on the Sorting Endosomes of 3Y1 Fibroblastic Cells
• Discrepancy in T_1 and T_2 Shortening of the Globus Pallidus in Hepatic Insufficiency : Evaluation by Susceptibility-weighted Imaging
• Intracellular Molecular Dynamics of N-Terminal Motif of Myristoylated Peptide
• Visualization of Ovarian Tumors using 3T MR Imaging : Diagnostic Effectiveness and Difficulties
• Pharmacological study of TA-0910, a new thyrotropin-releasing hormone(TRH) analog. (I). Effects on the central nervous system by oral administration.
• Pharmacological study of TA-0910, a new thyrotropin-releasing hormone(TRH) analog(II): Involvement of the DA system in the locomotor stimulating action of TA-0910.
• Pharmacological study of TA-0910, a new thyrotropin-releasing hormone(TRH) analog(III): Inhibition of pentobarbital anesthesia.
• Pharmacological study of TA-0910, a new thyrotropin-releasing hormone(TRH) analog. (IV). Effects on experimental memory impairment in mice and rats.
• Assembly of a Small DNA Rectangular Parallelepiped Block into Higher Order Nanostructures

もっと見る 閉じる

スポンサーリンク