EFFECTS OF ACETALDEHYDE ON THE MEMBRANE POTENTIAL AND MEMBRANE RESISTANCE OF THE IDENTIFIED NEURONS IN THE ABDOMINAL GANGLION OF <I>APLYSIA KURODAI</I>
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概要
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Actions of acetaldehyde on membrane potentials and membrane resistances of <I>Aplysia</I> neurons were studied using an intracellular recording and current injection technique. Several functionally different neurons in the abdominal ganglion of <I>A</I>. <I>kurodai</I> were identified on the basis of their morphological and electrophysiological characteristics. Application of between 5 and 50 mM acetaldehyde produced depolarization of the membrane, in all types of cells investigated. This depolarization was accompanied by an increase in the rate of spike discharge. The amplitude and the rates of rise and fall of the action potential were reduced and the duration of the spike was prolonged. Acetaldehyde had no significant effect on the input resistances of ganglion cells. These actions of the aldehyde were observed to be similar in the completely isolated neuron-soma preparation separated from the neighbouring cells or synapses.
- 社団法人 日本薬理学会の論文
著者
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TAKEDA Ryuji
Department of Pharmacology, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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Momose Yasunori
Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Toho University
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Takeda Ryuji
Department Of Orthopedic And Musculoskeletal Surgery Graduate School Of Medicine Kyoto University
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MOMOSE Yasunori
Department of Anatomy, Shinshu University School of Medicine
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MOMOSE Yasunori
Department of Pharmacology, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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