Contribution of NMDA Receptors to Activity of Augmenting Expiratory Neurons in Vagotomized Cats
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概要
- 論文の詳細を見る
To identify the NMDA receptor-mediated mechanism in augmenting expiratory(E2)neurons, the effects of systemic and local application of dizocilpine on spontaneous and evoked postsynaptic potentials(PSPs)were investigated in decerebrate and vagotomized cats.Intravenously applied dizocilpine reduced the inhibitory PSPs during inspiration and stage 1 expiration, but had little effect on the excitatory PSPs during stage 2 expiration.Iontophoresed dizocilpine caused a continuous hyperpolarization throughout the respiratory cycle.Dizocilpine had no effect on vagally evoked PSPs.These results suggest that the NMDA mechanisms are involved presynaptically in periodic postsynaptic inhibitions and postsynaptically in tonic excitation in E2 neurons.
- 社団法人 日本薬理学会の論文
- 2000-04-01
著者
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Okazaki Mari
Department Of Pharmacology Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Haji Akira
Department Of Pharmacology Faculty Of Medicine Toyama Medical And Pharmaceutical University
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TAKEDA Ryuji
Department of Pharmacology, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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Takeda Ryuji
Department Of Orthopedic And Musculoskeletal Surgery Graduate School Of Medicine Kyoto University
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Takeda Ryuji
Department Of Pharmacology Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Okazaki Mari
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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